TTLL12 is required for primary ciliary axoneme formation in polarized epithelial cells

ABSTRACT: The primary cilium is a critical sensory organelle that is built of axonemal microtubules ensheathed by a ciliary membrane. In polarized epithelial cells, primary cilia reside on the apical surface and must extend these microtubules directly into the extracellular space and remain a stable structure. However, the factors regulating cross-talk between ciliation and cell polarization, as well as axonemal microtubule growth and stabilization in polarized epithelia are not fully understood. In this study, we find TTLL12, a previously uncharacterized member of the Tubulin Tyrosine Ligase-Like (TTLL) family, localizes to the base of primary cilia and is required for cilia formation in polarized renal epithelial cells. We also show that TTLL12 directly binds to the /-tubulin heterodimer in vitr

SUBMITTER: Ms. Julia Ceglowski 

PROVIDER: S-SCDT-10_1038-S44319-023-00005-5 | biostudies-other |

REPOSITORIES: biostudies-other