ARL5b inhibits human rhinovirus 16 propagation and impairs macrophage-mediated bacterial clearance

ABSTRACT: Human rhinovirus is the most frequently isolated virus during severe exacerbations of chronic respiratory diseases, like chronic obstructive pulmonary disease. In this disease, alveolar macrophages display significantly diminished phagocytic functions that could be associated with bacterial superinfections. However, how human rhinovirus affects the functions of macrophages is largely unknown. Macrophages treated with HRV16 demonstrate deficient bacteria killing activity, impaired phagolysosome biogenesis and altered intracellular compartments. Using RNA sequencing, we identify the small GTPase ARL5b to be upregulated by the virus in primary human macrophages. Importantly, depletion of ARL5b rescues bacterial clearance and localization of endosomal markers in macrophages upon HRV16 exposure

SUBMITTER: Dr. Suzanne Faure-Dupuy 

PROVIDER: S-SCDT-10_1038-S44319-024-00069-X | biostudies-other |

REPOSITORIES: biostudies-other