TORC1 is an essential regulator of nutrient-controlled proliferation and differentiation in Leishmania

ABSTRACT: Leishmania parasites undergo differentiation between various proliferating and non-dividing forms to adapt to changing host environments. The mechanisms that link environmental cues with the parasite's developmental changes remain elusive. Here, we report that Leishmania TORC1 is a key environmental sensor for parasite proliferation and differentiation in the sand fly-stage promastigotes and for replication of mammalian-stage amastigotes. We show that Leishmania RPTOR1, interacts with TOR1 and LST8, and identify new parasite-specific proteins that interact in this complex. We investigate TORC1 function by conditional deletion of RPTOR1, where under nutrient-rich conditions RPTOR1 depletion results in decreased protein synthesis and growth, G1 cell cycle arrest and premature differentiatio

SUBMITTER: Dr. Elmarie Myburgh 

PROVIDER: S-SCDT-10_1038-S44319-024-00084-Y | biostudies-other |

REPOSITORIES: biostudies-other