Cellular remodeling and JAK inhibition promote zygotic gene expression in the Ciona germline

ABSTRACT: Transcription control is a major determinant of cell fate decisions in somatic tissues. By contrast, early germline fate specification in numerous vertebrate and invertebrate species relies extensively on RNA-level regulation, exerted on asymmetrically inherited maternal supplies, with little-to-no zygotic transcription. However delayed, a maternal-to-zygotic transition is nevertheless poised to complete the deployment of pre-gametic programs in the germline. Here, we focused on early germline specification in the tunicate Ciona to study zygotic genome activation. We first demonstrate that a peculiar cellular remodeling event excludes localized postplasmic Pem-1 mRNAs, which encodes the general inhibitor of transcription. Subsequently, zygotic transcription begins in Pem-1-negative primord

SUBMITTER: Dr. Naoyuki Ohta 

PROVIDER: S-SCDT-10_1038-S44319-024-00139-0 | biostudies-other |

REPOSITORIES: biostudies-other