The transcription factor PAX5 activates human LINE1 retrotransposons to induce cellular senescence

ABSTRACT: As a hallmark of senescent cells, the derepression of Long Interspersed Elements 1 (LINE1) transcription results in accumulated LINE1 cDNA, which triggers the secretion of the senescence-associated secretory phenotype (SASP) and paracrine senescence in a cGAS-STING pathway-dependent manner. However, transcription factors that govern senescence-associated LINE1 reactivation remain ill-defined. Here, we predict several transcription factors that bind to human LINE1 elements to regulate their transcription by analyzing the conserved binding motifs in the 5'-untranslational regions (UTR) of the commonly upregulated LINE1 elements in different types of senescent cells. Further analysis reveals that PAX5 directly binds to LINE1 5'-UTR and the binding is drastically enhanced in senescent cells. T

SUBMITTER: Dr. Huanyin Tang 

PROVIDER: S-SCDT-10_1038-S44319-024-00176-9 | biostudies-other |

REPOSITORIES: biostudies-other