Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity.

ABSTRACT: Signals emanating from the T cell receptor (TCR), co-stimulatory receptors, and cytokine receptors each influence CD8 T cell fate. Understanding how these signals respond to homeostatic and microenvironmental cues can reveal new ways to therapeutically direct T cell function. Through forward genetic screening in mice, we discover that loss-of-function mutations in LDL receptor related protein 10 (Lrp10) causes naïve and central memory CD8 T cells to accumulate in peripheral lymphoid organs. Lrp10 encodes a conserved cell surface protein of unknown immunological function. T cell activation induces Lrp10 expression, which post-translationally suppresses IL7 receptor (IL7R) levels. Accordingly, Lrp10 deletion enhances T cell homeostatic expansion through IL7R signaling. Lrp10-deficient mice a

SUBMITTER: Dr. Evan Nair-Gill 

PROVIDER: S-SCDT-10_1038-S44319-024-00191-W | biostudies-other |

REPOSITORIES: biostudies-other