Histone modifications and Sp1 promote GPR160 expression in bone cancer pain within rodent models

ABSTRACT: Bone cancer pain (BCP) affects approximately 70% of patients in advanced stages, primarily due to bone metastasis, presenting a substantial therapeutic challenge. Here, we profile orphan G protein-coupled receptors in the dorsal root ganglia (DRG) following tumor infiltration, and observe a notable increase in GPR160 expression. Elevated Gpr160 mRNA and protein levels persist from postoperative day 6 for over 18 days in the affected DRG, predominantly in small-diameter C-fiber type neurons specific to the tibia. Targeted interventions, including DRG microinjection of siRNA or AAV delivery, mitigate mechanical allodynia, cold, and heat hyperalgesia induced by the tumor. Tumor infiltration increases DRG neuron excitability in wild-type mice, but not in Gpr160 gene knockout mice. Tumor infilt

SUBMITTER: Prof. Huadong Ni 

PROVIDER: S-SCDT-10_1038-S44319-024-00292-6 | biostudies-other |

REPOSITORIES: biostudies-other