S100PBP interacts with the nucleoporin TPR and facilitates XY crossover formation in mice

ABSTRACT: During meiosis, at least one crossover is selectively generated per pair of homologous chromosomes through homologous recombination to ensure their faithful segregation. The molecular mechanisms controlling meiotic recombination, particularly in XY chromosomes that share a tiny region of homology (i.e. the pseudoautosomal region, PAR), remain poorly understood. Here, we identify S100PBP as a key modulator of both XY and autosomal recombination in mice. S100pbp-knockout mice exhibited male infertility and spermatogenesis arrest at meiotic metaphase I, resulting from a drastic reduction in XY crossovers. This failure in XY crossover formation is due to a reduction in TEX11/M1AP-bound recombination intermediates at the PAR. By contrast, disruption of S100PBP significantly increases the number

SUBMITTER: Yufan Wu 

PROVIDER: S-SCDT-10_1038-S44319-025-00391-Y | biostudies-other |

REPOSITORIES: biostudies-other