TCGEx: A Powerful Visual Interface for Exploring and Analyzing Cancer Gene Expression Data

ABSTRACT: Analyzing gene expression data from the Cancer Genome Atlas (TCGA) and similar repositories often requires advanced coding skills, creating a barrier for many researchers. To address this challenge, we developed The Cancer Genome Explorer (TCGEx), a user-friendly, web-based platform for conducting sophisticated analyses such as survival modeling, gene set enrichment analysis, unsupervised clustering, and linear regression-based machine learning. TCGEx provides access to preprocessed TCGA data and immune checkpoint inhibition studies while allowing integration of user-uploaded datasets. Using TCGEx, we explore molecular subsets of human melanoma and identify microRNAs associated with intratumoral immunity. These findings are validated with independent clinical trial data on immune checkpoin

SUBMITTER: Muhammet, Emre Kus 

PROVIDER: S-SCDT-10_1038-S44319-025-00407-7 | biostudies-other |

REPOSITORIES: biostudies-other