Characterization of meiotic axis proteins in the model brown alga Ectocarpus

ABSTRACT: Most eukaryotes share core meiosis-specific genes, suggesting meiosis evolved once in the last eukaryotic common ancestor (LECA). These genes are master regulators of meiotic recombination, ensuring genetically diverse lineages. However, meiosis in organisms outside the animal, plant and yeast lineages remains poorly understood. Core meiotic genes were recently identified in the model brown alga Ectocarpus but remain uncharacterised. Here, we combine bioinformatic, structural and biochemical approaches to characterise the axial-element orthologues meiotic Ectocarpus HORMA-domain protein (ecHOP1) and its interactor reductional division protein 1 (ecRED1), providing insight into meiotic-recombination regulation in brown algae. We define the chromatin-binding region of ecHOP1 and show it bind

SUBMITTER: Emma, I Kane 

PROVIDER: S-SCDT-10_1038-S44319-025-00605-3 | biostudies-other |

REPOSITORIES: biostudies-other