Early-stage lung adenocarcinoma affects DNA methylation and gene expression in adjacent tissues

ABSTRACT: The impact of early-stage tumors on gene expression in adjacent tissues remains uncertain, despite the known influence of the tumor microenvironment on tumor progression. Here, we systematically analyze early-stage lung adenocarcinoma (LUAD) and surrounding tissues across multiple distinct regions, from tumor core to distant tissues. DNA methylation profiling in a 12-patient cohort reveals two distinct patterns of methylation changes. Steep changes ocurring at the tumor boundary and shallow changes showing a gradual shift over increasing distance to the tumor. Approximately 17,000 CpG sites demonstrate shallow changing trends without clear boundaries, potentially affecting 2,655 genes. In half the patients, tissues within 10 mm beyond the tumor show methylation patterns similar to tumors.

SUBMITTER: Yifan Wu 

PROVIDER: S-SCDT-10_1038-S44319-025-00612-4 | biostudies-other |

REPOSITORIES: biostudies-other