Cyst-independent oocyte phagocytosis builds the female reproductive reserve in mice

ABSTRACT: During ovariogenesis, more than two-thirds of germ cells are sacrificed to improve the quality of the remaining oocytes. However, the detailed mechanisms behind this selection process are not fully understood in mammals. Here, we developed a high-resolution, four-dimensional ovariogenesis imaging system to track the progression of oocyte fate determination in live mouse ovaries. Through this, we identified a cyst-independent oocyte phagocytosis mechanism that plays a key role in determining oocyte survival. We found that oocytes act as individual cells, rather than connected cyst structures, during ovarian reserve construction. In this process, dominant oocytes capture and absorb cell debris from sacrificed oocytes to enrich their cytoplasm and support their survival. Single-cell sequencin

SUBMITTER: Hua Zhang 

PROVIDER: S-SCDT-10_1038-S44319-025-00663-7 | biostudies-other |

REPOSITORIES: biostudies-other