Actin waves guide an outward movement of microclusters in the lymphocyte immunological synapse

ABSTRACT: The lymphocyte immune response begins with antigen recognition on antigen-presenting cells, leading to the formation of the immunological synapse-a specialized interface for biochemical and biophysical exchange. At the synapse, most antigen-engaged receptor microclusters move inward toward the central supramolecular activation cluster (cSMAC) via retrograde F-actin flow, eventually clearing from the cell surface. This retrograde movement and receptor downregulation maintain antigen receptor homeostasis, critical for adaptive immunity, though its regulation remains unclear. Using live T cells, we identify a significant pool of antigen-engaged microclusters moving anterogradely toward the cell periphery, rather than the cSMAC. This movement is driven by actin waves propagating outward and co

SUBMITTER: Aheria Dey 

PROVIDER: S-SCDT-10_1038-S44319-025-00676-2 | biostudies-other |

REPOSITORIES: biostudies-other