McIdas localizes to centrioles and controls centriole numbers through PLK4-dependent phosphorylation

ABSTRACT: The centriole duplication cycle must be tightly controlled and coordinated with the chromosome cycle. Aberrations in centriole biogenesis can cause developmental disorders, ciliopathies and cancer, yet the molecular determinants controlling centriole numbers and the link between the two cycles remain poorly characterized. Here, we demonstrate that McIdas, previously implicated in cell cycle regulation and multiciliogenesis, plays a critical role in maintaining proper centriole numbers. McIdas localizes to centrioles, where it exhibits dynamic localization throughout the cell cycle, dependent upon a nuclear export signal (NES) in its coiled-coil domain. Overexpression of McIdas induces centriole overduplication, whereas its depletion perturbs daughter centriole biogenesis and SAS6 recruitme

SUBMITTER: Marina Arbi 

PROVIDER: S-SCDT-10_1038-S44319-026-00697-5 | biostudies-other |

REPOSITORIES: biostudies-other