Duox-driven ROS release by glia promotes regeneration in the adult Drosophila brain

ABSTRACT: Tissue damage activates immediate responses to restrict further harm and initiate repair. How injury sensing is coupled to regeneration is still not well understood. Here, we study regenerative responses in the adult Drosophila brain, where proliferation is normally strongly restricted. We show that localized brain damage triggers oxidative stress and diverse brain protective programs. We find that ROS generation by the NADPH Oxidase Duox in glial cells is responsible for injury-induced oxidative stress. Both genetic and chemical suppression of ROS in injured brains impairs regeneration. In particular, selective knockdown of calcium-sensitive duox in glia, which show elevated calcium after injury, reduces injury-induced proliferation. We further provide evidence that diffusing ROS can sust

SUBMITTER: Christa Rhiner 

PROVIDER: S-SCDT-10_1038-S44319-026-00703-W | biostudies-other |

REPOSITORIES: biostudies-other