Mechanical impact on neural stem cell lineage decisions in human brain organoids

ABSTRACT: During neurodevelopment neural stem cells give rise to a spatially patterned tissue in which a regionally differentially regulated balance between proliferation and differentiation produces the fine-tuned number of neurons and macroglia necessary for a functional central nervous system. The cells driving these highly intricated developmental processes of patterning, growth and differentiation are constantly exposed to a mechanical environment that is however variable between different brain regions and along differentiation trajectories. Here we demonstrate that both, acute mechanical manipulations as well as a persistent change in the mechanical environment provided to human brain organoids, instruct neural stem cell lineage decisions. Furthermore, we dissect the underlying changes in the

SUBMITTER: Sven Falk 

PROVIDER: S-SCDT-10_1038-S44319-026-00719-2 | biostudies-other |

REPOSITORIES: biostudies-other