Sirtuin 2 inhibits global protein synthesis via Rheb-GTPase degradation

ABSTRACT: Increased global protein synthesis is associated with the development and progression of several aging-related diseases and disorders. Strategies like calorie restriction and pharmacological inhibition of protein synthesis have exhibited health-promoting effects. However, the complex molecular events that regulate global protein synthesis are not completely understood. Here, we report that SIRT2, a histone deacetylase, negatively regulates global protein synthesis by inhibiting the mTORC1 pathway via deacetylating Rheb and promoting its degradation. Our in vitro results suggest that SIRT2 deficiency increases protein synthesis, whereas SIRT2 overexpression suppresses protein synthesis. SIRT2-deficient mice exhibit increased global protein synthesis in the hearts, which may contribute to th

SUBMITTER: Amarjeet Shrama 

PROVIDER: S-SCDT-10_1038-S44319-026-00724-5 | biostudies-other |

REPOSITORIES: biostudies-other