TPGS1 Regulates Central Spindle Microtubule Glutamylation and Remodeling During Telophase

ABSTRACT: Microtubules perform a variety of cellular functions including regulation of mitotic cell division, cilia formation, and neurite extension. Post-translational modifications controlled by the TTLL-family of enzymes confer a host of properties that affect microtubule dynamics and function. Specifically, polyglutamylation of tubulin C-terminal tails plays an important role in regulating microtubule dynamics and function within specific cellular contexts. In this study we examined contributions from and potential regulators of polyglutamylation during mitosis, focusing on the microtubule remodeling that occurs in telophase once the mitotic spindle has completed chromosome separation. We demonstrate that the anaphase-to-telophase transition is accompanied by an increase in short-chain polygluta

SUBMITTER: Rachel, K Sachs 

PROVIDER: S-SCDT-10_1038-S44319-026-00742-3 | biostudies-other |

REPOSITORIES: biostudies-other