Stn1 promotes zebrafish oocyte development via amplifying Wnt/β-catenin signaling

ABSTRACT: Wnt/β-catenin signaling regulates oocyte development in vertebrates. However, the dynamics of Wnt/β-catenin signaling in oocyte progression remains unclear. Here, we analyze oocytes across different developmental stages in zebrafish and find that the activity of Wnt/β-catenin signaling sharply increases when oocytes reach a size of 10 to 45 μm (stage IA to middle stage IB) and subsequently declines rapidly. In addition, we show that expression of the CST complex subunit Stn1 is enriched in germ cells. Stn1 interacts with the transcription factor Tcf/Lef, facilitates its association with promoters of germ cell-specific genes, thereby enhancing Wnt/β-catenin signaling activity in oocytes. Genetic deletion of stn1 leads to massive loss of oocytes prior to or during their development to stage

SUBMITTER: Xin Zhang 

PROVIDER: S-SCDT-10_1038-S44319-026-00775-8 | biostudies-other |

REPOSITORIES: biostudies-other