A Nanos3-containing protein complex can activate RNA translation in primordial germ cells in vivo

ABSTRACT: Maintaining the germline fate requires tight post-transcriptional control of RNA function. Here, we investigate how primordial germ cell (PGC) identity is maintained in zebrafish and reveal that the conserved RNA-binding proteins Nanos3 and Dead End1 form a complex that safeguards PGC identity. Using transcriptomics and in vivo imaging-based analyses, we show that this complex controls the translational activation and localization of both nanos3 and dead end1 RNAs, establishing a positive feedback loop crucial for regulating their protein expression. These findings uncover a previously unknown layer of control over germline development, where a complex containing Nanos3, a protein associated with the inhibition of RNA translation, acts as an activator by interacting with an eIF3 complex pr

SUBMITTER: Antra Gupta 

PROVIDER: S-SCDT-10_1038-S44319-026-00781-W | biostudies-other |

REPOSITORIES: biostudies-other