Age-related decline in nuclear envelope LINC complex drives neuronal aging via axon initial segment dysfunction

ABSTRACT: Brain aging is an intricate process that inevitably leads to functional deterioration. However, its molecular drivers remain unclear. Here, we show that the age-related decline in LINC complex expression on the neuronal nuclear envelope impairs axon initial segment (AIS)-mediated excitability and triggers brain aging. With aging, the expression of LINC complex components, including Sun1, decreases in various brain regions, accompanied by a reduction in AIS length. Preserving Sun1 expression rescues nuclear structural abnormalities in aged neurons, shifting chromatin dynamics and global gene expression toward those of young neurons. Particularly, it restores the expression of AIS-related molecules, including voltage-gated sodium or potassium channels essential for action potential generatio

SUBMITTER: Koichi Hasegawa 

PROVIDER: S-SCDT-10_1038-S44319-026-00786-5 | biostudies-other |

REPOSITORIES: biostudies-other