Noncanonical IRF3 function mediates STING-dependent pro-inflammatory cytokine production in macrophages

ABSTRACT: STING is an important component in the host innate immune system where its activation by cyclic dinucleotides culminates in the production of interferons and proinflammatory cytokines that mediate host defence against infection. While the mechanisms that govern STING-induced interferon production have been comprehensively characterised, how pro-inflammatory cytokines are produced downstream of STING remains less understood. Here we discover that IRF3 is critical for effective STING-mediated inflammatory cytokine production from macrophages as those lacking IRF3 display significant defects. Interestingly, the loss of IRF3 does not impact the activation of the prominent pro-inflammatory transcription factor, NF-B, but rather affects the AP-1 transcriptional complex. We further discover the

SUBMITTER: Katherine, R Balka 

PROVIDER: S-SCDT-10_1038-S44319-026-00793-6 | biostudies-other |

REPOSITORIES: biostudies-other