Bacterial lipid synthesizing enzymes PlsY and PlsC utilize both stereo-forms of glycerol-phosphate

ABSTRACT: The central dogma posits that the stereochemistry of phospholipids in bacteria is distinct from archaea. Bacterial phospholipids consist of fatty acid lipid tails esterified to the sn-glycerol-3-phosphate lipid backbone (G3P), whereas archaeal phospholipids comprise isoprenoid lipid tails ether-linked to the stereochemical different sn-glycerol-1-phosphate (G1P). This segregation, the "lipid divide", is however not as strict as previously thought. Recent reports demonstrate that both glycerol-phosphate backbones are present in phospholipids from various Gram-positive bacteria. To test if the stereochemical variability can be attributed to conventional lipid biosynthesis, we characterize the stereospecificity of the relevant glycerol-phosphate acyl transferases PlsY and PlsB, as well as the

SUBMITTER: Philipp Rieche 

PROVIDER: S-SCDT-10_1038-S44319-026-00827-Z | biostudies-other |

REPOSITORIES: biostudies-other