CD8 T lymphocytes deploy embryonic cell cycle control mechanisms for rapid cell proliferation

ABSTRACT: Rapid proliferation of CD8 T cells is crucial for adaptive immunity against viral infection. CD8 T cells can complete division cycles in less than 6 hours, representing a physiological extreme for somatic mammalian cells. Embryonic stem cells utilize specialized cell cycle control mechanisms, including subdued periodic expression, for rapid cell division cycles. CD8 T cell cycle control remains poorly understood. Here, we test whether CD8 T cells utilize embryonic mechanisms to promote rapid cell cycles. We comprehensively measure protein abundances in G1, S and G2&M phases in three murine cell types: CD8 T cells, embryonic stem cells and fibroblasts. We discover striking similarities between mESC and CD8 T cells. We demonstrate that CD8 T cells express Cyclin E1 and Emi1/Fbxo5 at high lev

SUBMITTER: David Lewis 

PROVIDER: S-SCDT-10_1038-S44319-026-00830-4 | biostudies-other |

REPOSITORIES: biostudies-other