Arf1 is involved in Neisseria meningitidis-induced cortical branched F-actin network reorganization

ABSTRACT: Cells experience external forces that deform the plasma membrane to which they adapt by reorganizing their actin cytoskeleton. Here, using the extracellular bacterium Neisseria meningitidis as a model system, we explore how this bacterium reorganizes the cortical actin cytoskeleton subsequently to mechanical membrane deformations. Meningococci trigger the formation of tubular cellular plasma membrane protrusions by a previously described adhesion-driven process known as one-dimensional wetting. Cryo-electron tomography reveals that in epithelial cells such a deformation of the plasma membrane leads to the formation of F-actin bundles. In contrast, in endothelial cells a branched F-actin network is formed. By combining high resolution photonic microscopy approaches with genetic and drug per

SUBMITTER: Margot Sahnine 

PROVIDER: S-SCDT-10_1038-S44319-026-00843-Z | biostudies-other |

REPOSITORIES: biostudies-other