Transcriptional perturbation of LINE-1 elements reveals their cis-regulatory potential

ABSTRACT: Long interspersed element-1 (L1) retrotransposons constitute the largest transposable element family in mammalian genomes and contribute prominently to inter- and intra-individual genetic variation. Although most L1 elements are inactive, some evolutionary younger elements remain intact and genetically competent for transcription and occasionally retrotransposition. Despite being generally more abundant in gene-poor regions, intact or full-length L1s (FL-L1) are also enriched around specific classes of genes and on the eutherian X chromosome. How proximal FL-L1 may affect nearby gene expression remains unclear. Here, we examine this systematically using engineered mouse embryonic stem cells (ESCs) in which expression of one active L1 subfamily is perturbed. We find that FL-L1 activation le

SUBMITTER: Yuvia, A. Pérez-Rico 

PROVIDER: S-SCDT-10_1038-S44319-026-00854-W | biostudies-other |

REPOSITORIES: biostudies-other