Glycolytic suppression of cell adhesion promotes thyroid morphogenesis in response to nutrition

ABSTRACT: Organ morphogenesis relies on collective cellular behaviors. While intrinsic developmental programs governing cellular behaviors are well characterized, the effects of environmental and systemic factors on these behaviors remain poorly understood. Here, we investigate how nutritional availability modulates cellular behaviors during thyroid morphogenesis using Xenopus tadpoles as an in vivo model. RNA-seq analysis of thyroid regions from fed and unfed tadpoles shows that nutritional status alters gene expression profiles. We identify cell adhesion-related genes as key targets, with expression increased in unfed tadpoles and decreased in fed tadpoles. Immunostaining for E-cadherin supports the RNA-seq results, and functional inhibition of E-cadherin facilitates thyroid follicle formation. We

SUBMITTER: Asako Shindo 

PROVIDER: S-SCDT-10_1038-S44319-026-00868-4 | biostudies-other |

REPOSITORIES: biostudies-other