PPARG directs trophoblast cell fate and establishment of the uterine-placental interface

ABSTRACT: The expansion and differentiation of trophoblast stem (TS) cells are critical for defining fundamental properties of the placenta. Specialized trophoblast cells called extravillous trophoblast (EVT) cells in human and invasive trophoblast cells in rat, exit the placenta, enter and transform the uterus. This includes the restructuring of uterine spiral arteries, essential for the transfer of nutrients to the fetus. Mechanisms governing invasive trophoblast cell differentiation remain poorly understood. Here, we investigate peroxisome proliferator-activated receptor gamma (PPARG) as a potential regulator of EVT/invasive trophoblast cell development. In first trimester human placentas, PPARG is expressed in the EVT cell column and increases in amount as human TS cells differentiate into EVT c

SUBMITTER: Esteban, M Dominguez 

PROVIDER: S-SCDT-10_1038-S44319-026-00896-0 | biostudies-other |

REPOSITORIES: biostudies-other