Vimentin Loss Inhibits DNA Damage Responses and Promotes Cancer Cell Survival.

ABSTRACT: Vimentin intermediate filaments are a hallmark of aggressive tumors and are widely linked to invasion and EMT, yet how vimentin-dependent mechanics shape genome maintenance and therapy response is unclear. Here we show that vimentin, particularly under compressive load, promotes DNA repair competence. In contrast, vimentin negative cells show impaired DNA damage sensing and downstream signaling, ultimately leading to decreased apoptosis and promoting cell survival under genotoxic stress at the expense of genomic stability. Using controlled cell compression together with genetic and pharmacological perturbations, we find that loss of vimentin of glioblastoma cells limit the expression and activity of core repair pathways because of induced nuclear mechanical compression. Relieving nuclear c

SUBMITTER: Elvira Infante 

PROVIDER: S-SCDT-10_1038-S44319-026-00913-2 | biostudies-other |

REPOSITORIES: biostudies-other