Aurora A Exacerbates Antibiotic-Resistant Staphylococcus aureus Infection through ASC Phosphorylation

ABSTRACT: Excessive inflammasome activation is increasingly recognized as a critical driver of pathology during bacterial infections, yet the pathogen-derived mechanisms that trigger dysregulated inflammasome responses remain poorly defined. Here, we identify a previously unrecognized role for the serine/threonine kinase Aurora A in promoting inflammasome activation during Staphylococcus aureus infection. We demonstrate that S. aureus activates JNK-dependent signaling in macrophages, leading to the phosphorylation of Aurora A. Activated Aurora A directly phosphorylates ASC, the inflammasome adaptor, on serine residues, enhancing ASC oligomerization and facilitating robust caspase-1 activation through both NLRP3 and AIM2 inflammasomes. This phosphorylation event stabilizes ASC speck formation and amp

SUBMITTER: Hajime Yamauchi 

PROVIDER: S-SCDT-10_1038-S44319-026-00918-X | biostudies-other |

REPOSITORIES: biostudies-other