Greatwall Kinase regulates Acute Myeloid Leukaemia Cell Divi- sion through a Non-Canonical Mechanism

ABSTRACT: Greatwall kinase regulates mitotic progression by phosphorylating ENSA and ARPP19, thereby inhibiting PP2A-B55. Moreover, Greatwall has been implicated in oncogenesis, particularly in solid tumours, but the mechanisms by which Greatwall regulates the cell cycle in other malignancies remain unclear. Here, we show that Greatwall regulates cytokinesis and cell cycle progression in acute myeloid leukaemia (AML) cells through a pathway distinct from ENSA-PP2A-B55. AML cells require Greatwall expression and activity to proliferate, as revealed by pharmacological and systematic genetic perturbation experiments. Mechanistically, Greatwall inactivation or genetic depletion does not measurably affect the ENSA-PP2A-B55 pathway. Instead, loss of Greatwall function alters cytokinesis, and the phosphory

SUBMITTER: Sandra, M. Martin-Guerrero 

PROVIDER: S-SCDT-10_1038-S44319-026-00955-6 | biostudies-other |

REPOSITORIES: biostudies-other