Endogenous rhythms in deep-sea mussel cell culture and molecular clock characterization

ABSTRACT: While biological rhythms are crucial to life, the deep sea has long been considered an arrhythmic exception. However, at hydrothermal vents - devoid of diel cues yet shaped by tides - the mussel Bathymodiolus azoricus shows both tidal and, unexpectedly, circadian rhythms at -1700 m. Whether endogenous clock(s) drive these cycles remained unanswered. Here, we report endogenous circadian rhythms in B. azoricus cell cultures under constant conditions: isolated cells display a circadian oscillation despite tidal-dominant rhythms in the natural environment. Reporter assays using genomic regions upstream of the mussel's per gene and containing E-box motifs suggest that a functional transcription-translation feedback loop (TTFL) contributes to circadian timing even in the deep sea. In mussels, Ba

SUBMITTER: Audrey, M Mat 

PROVIDER: S-SCDT-10_1038-S44319-026-00970-7 | biostudies-other |

REPOSITORIES: biostudies-other