CD90 delineates distinct muscle stem cell states of quiescence and activation

ABSTRACT: Stem cell transition from quiescence to activation is crucial to guarantee productive tissue regeneration. Here, we show that CD90 expression diversifies quiescent muscle stem cells (MuSCs) in murine and human muscle into two subsets differing in the kinetics of activation. CD90+ve MuSCs exhibit a faster exit from quiescence and predominate the initial phases of regeneration compared to CD90-ve MuSCs. In the absence of injury, the CD90+ve fraction is primed towards activation through an active CD90-AMPK axis but is maintained in quiescence through signals from the extracellular matrix. We further show that Collagen VI, which is preferentially expressed by CD90+ve MuSCs, binds to the Calcitonin receptor. Moreover, while the number of CD90+ve and CD90-ve MuSCs is similar in healthy muscles,

SUBMITTER: Eyemen Kheir 

PROVIDER: S-SCDT-10_1038-S44319-026-00980-5 | biostudies-other |

REPOSITORIES: biostudies-other