The Arp2/3 complex maintains genome integrity and survival of epidermal Langerhans cells

ABSTRACT: Myeloid cells use intracellular actin networks for key cellular processes, including cell migration and chemotaxis, phagocytosis or macropinocytosis, as well as immune synapse formation. However, whether actin networks play any role in the development and/or survival of myeloid cells in tissues remains open. Here, we find that the Arp2/3 complex, which is responsible for the nucleation of branched actin networks, is needed for in vivo maintenance of epidermal Langerhans cells (LCs) throughout life. Mice harboring a genetic deletion of the Arpc4 subunit of the complex in myeloid cells form LC networks at birth, but these cells decline in numbers following a process reminiscent of premature cellular aging. By combining in vivo analyses of LCs with in vitro experiments on bone-marrow-derived

SUBMITTER: Maria-Graciela Delgado 

PROVIDER: S-SCDT-10_1038-S44319-026-00982-3 | biostudies-other |

REPOSITORIES: biostudies-other