Integrated annotation prioritizes metabolites with bioactivity in inflammatory bowel disease

ABSTRACT: Microbial biochemistry is central to the pathophysiology of inflammatory bowel diseases (IBD). Improved knowledge of microbial metabolites and their immunomodulatory roles is thus necessary for diagnosis and management. Here, we systematically analyzed the chemical, ecological, and epidemiological properties of ~82k metabolic features in 546 Integrative Human Microbiome Project (iHMP/HMP2) metabolomes, using newly developed methodology for bioactive compound prioritization from microbial communities. This suggested >1,000 metabolic features as potentially bioactive in IBD and associated ~43% of prevalent, unannotated features with at least one well-characterized metabolite, thereby providing initial information for further characterization of a significant portion of the fecal metabolom

SUBMITTER: Amrisha Bhosle 

PROVIDER: S-SCDT-10_1038-S44320-024-00027-8 | biostudies-other |

REPOSITORIES: biostudies-other