Exogenous Prion-Like Proteins and Their Potential to Trigger Cognitive Dysfunction

ABSTRACT: The gut is exposed to a wide range of proteins, including ingested proteins and those produced by the resident microbiota. While ingested prion-like proteins can propagate across species, their implications for disease development remain largely unknown. Here, we apply a multidisciplinary approach to examine the relationship between the biophysical properties of exogenous prion-like proteins and the phenotypic consequences of ingesting them. Through computational analysis of gut bacterial proteins, we identified an enrichment of prion-like sequences in Helicobacter pylori. Based on these findings, we rationally designed a set of synthetic prion-like sequences that form amyloid fibrils, interfere with amyloid-beta-peptide aggregation, and trigger prion propagation when introduced in the yea

SUBMITTER: Jofre Seira Curto 

PROVIDER: S-SCDT-10_1038-S44320-025-00114-4 | biostudies-other |

REPOSITORIES: biostudies-other