Genetics-mediated regulation of intestinal gene expression on microbiome contributes to human disease heritability

ABSTRACT: The gut microbiome plays fundamental roles in physiological and pathological processes, yet its interaction with host gene expression and contribution to disease remain underexplored. Here, we integrate the genetic regulatory maps of 116 microbial genera with gene expression quantitative trait loci (eQTLs) and DNA methylation QTLs (mQTLs) in three intestinal tissues to dissect host-microbiome interaction. We identify 6,088, 5,810 and 2,398 gene-to-microbiome regulatory loci in transverse colon, sigmoid colon, and ileum, respectively. Among these, 13.2% of genes show broad regulatory effects on multiple genera, with functional enrichments in developmental, metabolic, and immune-related pathways. Integrative analysis with genome-wide association studies (GWASs) reveals 283 microbiome-depende

SUBMITTER: Haochuan Wang 

PROVIDER: S-SCDT-10_1038-S44320-025-00173-7 | biostudies-other |

REPOSITORIES: biostudies-other