The evolutionary dynamics between viral mimics and host proteins

ABSTRACT: Viral proteins interact with host proteins to hijack cellular pathways important for viral replication. Viral mimics are proteins whose structural similarity to host-mimicked proteins allows them to interact with mutual host targets. This mimicry poses a challenge for the host - how to avoid mimics without compromising essential interactions with host-mimicked proteins. Despite the prevalence of mimicry, the evolutionary dynamics between host and viral mimics remain largely unknown. We address this by integrating structural modelling, host-virus interaction networks and comprehensive evolutionary analyses of host and viral proteins. We show that host proteins targeted by mimics and host-mimicked proteins are highly conserved, and that this is related to functional constraints imposed on ho

SUBMITTER: Rotem Fuchs 

PROVIDER: S-SCDT-10_1038-S44320-026-00200-1 | biostudies-other |

REPOSITORIES: biostudies-other