Cross-Species Insights from ART-D to Uncover Evolutionarily Conserved Oncogenic Mechanisms

ABSTRACT: Cancer arises from oncogenic clones, yet the dynamic mechanisms driving their stepwise evolution toward malignancy remain incompletely understood. Here, we establish the Atlas of Ras-driven Tumors in Drosophila (ART-D), a systematic, cross-species platform that dissects the molecular and phenotypic trajectories of tumorigenesis across ten genetically defined RasV12-driven models. By integrating longitudinal phenotypic profiling, we define three conserved stages of tumor development-initiation, promotion, and progression-distinguished by distinct shifts in tumor burden and tumor-induced cachexia. Transcriptomic analysis reveals stage-specific signaling rewiring: early tumorigenesis is characterized by co-activation of JAK/STAT, NF-κB/Toll, and MAPK pathways, whereas malignant progression is

SUBMITTER: Yifan Guo 

PROVIDER: S-SCDT-10_1038-S44320-026-00215-8 | biostudies-other |

REPOSITORIES: biostudies-other