Joint-RPCA: Domain-Aware Multi-Omics Integration for Systems Microbiology

ABSTRACT: Integrating multi-omics data is essential for microbiome research, as microbial communities are shaped by and respond to interdependent processes, including taxonomic composition, metabolite production and utilization, and gene expression. However, accurately capturing ecosystem-wide patterns across these modalities is statistically challenging due to differences in scale, sparsity, and compositionality. While a growing number of multi-omics methods have emerged, they differ in their mathematical objectives and modeling assumptions, which in turn shape how biological patterns are represented and interpreted. This underscores the need for tools that explicitly account for the statistical properties of microbial ecosystems. Here, we present Joint Robust Principal Component Analysis (Joint-RP

SUBMITTER: Bianca Cordazzo Vargas 

PROVIDER: S-SCDT-10_1038-S44320-026-00236-3 | biostudies-other |

REPOSITORIES: biostudies-other