Integrated spatial multiomics reveals early mechanisms driving high grade serous ovarian carcinoma

ABSTRACT: High-grade serous carcinoma (HGSC) is the most common ovarian cancer subtype, typically diagnosed at late stages with poor prognosis. Understanding early molecular events driving HGSC progression is crucial for timely detection and therapeutic intervention. We performed and integrated spatial cell-type-resolved proteomics and paired transcriptomics across 25 women with precursor lesions of the fallopian tube and/or HGSC. Epithelial signatures revealed early activation of SUMOylation, increased ATR and Wnt signaling along the disease trajectory. The stroma exhibited extracellular matrix remodeling, interferon-mediated inflammation, and enhanced MHC-I antigen presentation. Serous tubal intraepithelial carcinomas (STICs) in cancer patients showed a pro-coagulative signature and reduced APOA1/

SUBMITTER: Andreas Metousis 

PROVIDER: S-SCDT-10_1038-S44320-026-00253-2 | biostudies-other |

REPOSITORIES: biostudies-other