Interferon-epsilon is a novel regulator of NK cell responses in the uterus

ABSTRACT: The uterus is a unique mucosal site where immune responses are balanced to be permissive of a fetus, yet protective against infections. Regulation of natural killer (NK) cell responses in the uterus during infection is critical, yet no studies have identified uterine-specific factors that control NK cell responses in this immune-privileged site. We show that the constitutive expression of IFNε in the uterus plays a crucial role in promoting the accumulation, activation, and IFNγ production of NK cells in uterine tissue during Chlamydia infection. Uterine epithelial IFNε primes NK cell responses indirectly by increasing IL-15 production by local immune cells and directly by promoting the accumulation of a pre-pro-like NK cell progenitor population and activation of NK cells in the uterus. T

SUBMITTER: Prof. Philip, M Hansbro 

PROVIDER: S-SCDT-10_1038-S44321-023-00018-6 | biostudies-other |

REPOSITORIES: biostudies-other