Inhibition of SFTSV replication in humanized mice by a subcutaneously administered anti-PD1 nanobody

ABSTRACT: Severe fever with thrombocytopenia syndrome (SFTS) is a life-threatening disease caused by a novel bunyavirus (SFTSV), mainly transmitted by ticks. With no effective therapies or vaccines available, understanding the disease's mechanisms is crucial. Recent studies found increased expression of programmed cell death-1 (PD-1) on dysfunctional T cells in SFTS patients. However, the role of the PD-1/programmed cell death-ligand 1 (PD-L1) pathway in SFTS progression remains unclear. We investigated PD-1 blockade as a potential therapeutic strategy against SFTSV replication. Our study analyzed clinical samples and performed in vitro experiments, revealing elevated PD-1/PD-L1 expression in various immune cells following SFTSV infection. An anti-PD1 nanobody, NbP45, effectively inhibited SFTSV inf

SUBMITTER: Dr. mengmeng Ji 

PROVIDER: S-SCDT-10_1038-S44321-024-00026-0 | biostudies-other |

REPOSITORIES: biostudies-other