Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson's patients

ABSTRACT: Synucleinopathies such as Parkinson's disease (PD) are defined by the accumulation and aggregation of the α-synuclein protein in neurons and glia and other tissues. We have previously shown that destabilization of α-synuclein tetramers is associated with familial PD due to SNCA mutations and demonstrated brain-region specific alterations of α-synuclein multimers in sporadic PD patients following the classical Braak spreading theory. In this study, we assessed relative levels of disordered and higher-ordered multimeric forms of cytosolic α-synuclein in blood from familial PD with G51D mutations and sporadic PD patients. We used an adapted in vitro-crosslinking protocol for human EDTA-whole blood. The relative levels of higher-ordered α-synuclein tetramers were diminished in blood from famil

SUBMITTER: Dr. Laura de Boni 

PROVIDER: S-SCDT-10_1038-S44321-024-00083-5 | biostudies-other |

REPOSITORIES: biostudies-other