Minimally-invasive Implantable Device Enhances Brain Cancer Suppression

ABSTRACT: Current brain tumor treatments are limited by the skull and BBB, leading to poor prognosis and short survival for glioma patients. We introduce a novel minimally-invasive brain tumor suppression (MIBTS) device combining personalized intracranial electric field therapy with in-situ chemotherapeutic coating. The core of our MIBTS technique is a wireless-ultrasound-powered, chip-sized, lightweight device with all functional circuits encapsulated in a small but efficient "Swiss-roll" structure, guaranteeing enhanced energy conversion while requiring tiny implantation windows (~3*5 mm), which favors broad consumers acceptance and easy-to-use of the device. Compared with existing technologies, competitive advantages in terms of tumor suppressive efficacy and therapeutic resolution were noticed,

SUBMITTER: Xiaona Cao 

PROVIDER: S-SCDT-10_1038-S44321-024-00091-5 | biostudies-other |

REPOSITORIES: biostudies-other