Platelet transcription factors license the pro-inflammatory cytokine response of human monocytes.

ABSTRACT: Classical CD14+ monocytes in human blood contribute to host defense by secreting large amounts of pro-inflammatory cytokines. Their aberrant activity causes hyper-inflammation and life-threatening cytokine storms, while dysfunctional monocytes are associated with 'immunoparalysis', a state of immune hypo responsiveness and reduced pro-inflammatory gene expression, predisposing individuals to opportunistic infections. Understanding how monocyte functions are regulated is therefore paramount. We reveal platelets' vital role in human monocytes' pro-inflammatory cytokine responses. Naturally, low platelet counts in immune thrombocytopenia or removal of platelets from healthy monocytes result in monocyte immunoparalysis, marked by impaired cytokine response to immune challenge and weakened host

SUBMITTER: Dr. Ibrahim Hawwari 

PROVIDER: S-SCDT-10_1038-S44321-024-00093-3 | biostudies-other |

REPOSITORIES: biostudies-other