Experimental vaccination by single dose sporozoite injection of blood stage attenuated malaria parasites

ABSTRACT: Malaria vaccination approaches using live Plasmodium parasites are currently explored, with either attenuated mosquito-derived sporozoites or attenuated blood stage parasites. Both approaches would profit from the availability of attenuated and avirulent parasites with a reduced blood stage multiplication rate. Here we screened gene-deletion mutants of the rodent parasite P. berghei and the human parasite P. falciparum for slow growth. Furthermore, we tested the P. berghei mutants for avirulence and resolving blood stage infections, while preserving sporozoite formation and liver infection. Targeting 51 genes yielded 18 P. berghei gene-deletion mutants with several mutants causing mild infections. Infections with the two most attenuated mutants either by blood stages or by sporozoites were

SUBMITTER: Dr. Julia, Magdalena Sattler 

PROVIDER: S-SCDT-10_1038-S44321-024-00101-6 | biostudies-other |

REPOSITORIES: biostudies-other