Infection length and host environment influence on Plasmodium falciparum dry season reservoir

ABSTRACT: Persistence of malaria parasites in asymptomatic hosts is crucial in areas of seasonally-interrupted transmission. Extended circulation of erythrocytes infected by Plasmodium falciparum without cytoadhering has been associated with long-lasting dry season infections, but the factors determining parasite persistence remain poorly understood. Here, we investigated whether seasonality affects plasma composition so that parasites adjust to serological cues; or if alternatively, infection duration dictates clinical presentation and persistency. Data from Malian children exposed to alternating wet and dry seasons, show that plasma composition is unrelated to time of year or subclinical infection; and that seasonally-collected plasmas do not affect parasite replication or host cell remodelling in

SUBMITTER: Carolina, M Andrade 

PROVIDER: S-SCDT-10_1038-S44321-024-00127-W | biostudies-other |

REPOSITORIES: biostudies-other