Liver protects neuron viability and electrocortical activity in post-cardiac arrest brain injury

ABSTRACT: Brain injury is the leading cause of mortality among patients who survive cardiac arrest (CA). Clinical studies have shown that the presence of post-CA hypoxic hepatitis or pre-CA liver disease is associated with increased mortality and inferior neurological recovery. In our in vivo global cerebral ischemia model, we observed a larger infarct area, elevated tissue injury scores, and increased intravascular CD45+ cell adhesion in reperfused brains with simultaneous hepatic ischemia than in those without it. In the ex vivo brain normothermic machine perfusion (NMP) model, we demonstrated that addition of a functioning liver to the brain NMP circuit significantly reduced post-CA brain injury, increased neuronal viability, and improved electrocortical activity. Furthermore, significant alterat

SUBMITTER: Prof. Zhiyong Guo 

PROVIDER: S-SCDT-10_1038-S44321-024-00140-Z | biostudies-other |

REPOSITORIES: biostudies-other