Alpha-synuclein misfolding as fluid biomarker for Parkinson's disease measured with the iRS platform

ABSTRACT: Misfolding and aggregation of alpha-synuclein (αSyn) play a key role in the pathophysiology of Parkinson's disease (PD). Despite considerable advances in diagnostics, an early and differential diagnosis of PD still represents a major challenge. We innovated the immuno-infrared sensor (iRS) platform for measuring αSyn misfolding. We analyzed cerebrospinal fluid (CSF) from two cohorts comprising PD cases, atypical Parkinsonian disorders, and disease controls. We obtained an AUC of 0.90 (n=134, 95 %-CL 0.85-0.96) for separating PD/MSA from controls by determination of the αSyn misfolding by iRS. Using two thresholds divided individuals as unaffected/affected by misfolding with an intermediate area in between. Comparing the affected/unaffected cases, controls versus PD/MSA cases were classifie

SUBMITTER: Martin Schuler 

PROVIDER: S-SCDT-10_1038-S44321-025-00229-Z | biostudies-other |

REPOSITORIES: biostudies-other